diff --git a/.github/workflows/nexus.yml b/.github/workflows/nexus.yml
new file mode 100644
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+++ b/.github/workflows/nexus.yml
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+#
+#  Copyright (c) 2026, The OpenThread Authors.
+#  All rights reserved.
+#
+#  Redistribution and use in source and binary forms, with or without
+#  modification, are permitted provided that the following conditions are met:
+#  1. Redistributions of source code must retain the above copyright
+#     notice, this list of conditions and the following disclaimer.
+#  2. Redistributions in binary form must reproduce the above copyright
+#     notice, this list of conditions and the following disclaimer in the
+#     documentation and/or other materials provided with the distribution.
+#  3. Neither the name of the copyright holder nor the
+#     names of its contributors may be used to endorse or promote products
+#     derived from this software without specific prior written permission.
+#
+#  THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
+#  AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+#  IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
+#  ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
+#  LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
+#  CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
+#  SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
+#  INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
+#  CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
+#  ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE
+#  POSSIBILITY OF SUCH DAMAGE.
+#
+
+name: Nexus
+
+on:
+  push:
+    branches-ignore:
+      - 'dependabot/**'
+  pull_request:
+    branches:
+      - 'main'
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.event.pull_request.number || (github.repository == 'openthread/openthread' && github.run_id) || github.ref }}
+  cancel-in-progress: true
+
+permissions:
+  contents: read
+
+jobs:
+
+  nexus-tests:
+    runs-on: ubuntu-24.04
+    steps:
+    - name: Harden Runner
+      uses: step-security/harden-runner@e3f713f2d8f53843e71c69a996d56f51aa9adfb9 # v2.14.1
+      with:
+        egress-policy: audit
+
+    - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # v5.0.0
+      with:
+        submodules: recursive
+
+    - name: Bootstrap
+      run: |
+        sudo apt-get update
+        sudo DEBIAN_FRONTEND=noninteractive apt-get --no-install-recommends install -y ninja-build tshark
+        python3 -m pip install -r tests/scripts/thread-cert/requirements.txt
+
+    - name: Build Nexus
+      run: |
+        mkdir -p build/nexus
+        top_builddir=build/nexus ./tests/nexus/build.sh
+
+    - name: Run Nexus Tests
+      run: |
+        top_builddir=build/nexus ./tests/nexus/run_nexus_tests.sh