diff --git a/CMakeLists.txt b/CMakeLists.txt
index 71eb77ead..f4500181d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -122,15 +122,21 @@ list(APPEND OT_PUBLIC_INCLUDES ${PROJECT_SOURCE_DIR}/include)
 if(OT_PLATFORM STREQUAL "posix")
     target_include_directories(ot-config INTERFACE ${PROJECT_SOURCE_DIR}/src/posix/platform)
     target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_POSIX=1)
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_NEXUS=0)
     add_subdirectory("${PROJECT_SOURCE_DIR}/src/posix/platform")
 elseif(OT_PLATFORM STREQUAL "external")
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_POSIX=0)
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_NEXUS=0)
     # skip in this case
 elseif(OT_PLATFORM STREQUAL "nexus")
     if (OT_APP_CLI OR OT_APP_NCP OR OT_APP_RCP)
         message(FATAL_ERROR "no app (cli/ncp/rcp) should be enabled with nexus simulation platform")
     endif()
     target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_NEXUS=1)
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_POSIX=0)
 else()
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_POSIX=0)
+    target_compile_definitions(ot-config INTERFACE OPENTHREAD_PLATFORM_NEXUS=0)
     target_include_directories(ot-config INTERFACE ${PROJECT_SOURCE_DIR}/examples/platforms/${OT_PLATFORM})
     add_subdirectory("${PROJECT_SOURCE_DIR}/examples/platforms/${OT_PLATFORM}")
 endif()
diff --git a/src/cli/ftd.cmake b/src/cli/ftd.cmake
index 7b6f08a00..ce9966207 100644
--- a/src/cli/ftd.cmake
+++ b/src/cli/ftd.cmake
@@ -37,6 +37,7 @@ target_compile_definitions(openthread-cli-ftd
 
 target_compile_options(openthread-cli-ftd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-cli-ftd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/cli/mtd.cmake b/src/cli/mtd.cmake
index 733bfaaa9..f5f035f73 100644
--- a/src/cli/mtd.cmake
+++ b/src/cli/mtd.cmake
@@ -37,6 +37,7 @@ target_compile_definitions(openthread-cli-mtd
 
 target_compile_options(openthread-cli-mtd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-cli-mtd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/cli/radio.cmake b/src/cli/radio.cmake
index 47652d2c6..709a84ca8 100644
--- a/src/cli/radio.cmake
+++ b/src/cli/radio.cmake
@@ -38,6 +38,7 @@ target_compile_definitions(openthread-cli-radio
 
 target_compile_options(openthread-cli-radio PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-cli-radio PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/core/config/misc.h b/src/core/config/misc.h
index f7e986830..fe5aaa62f 100644
--- a/src/core/config/misc.h
+++ b/src/core/config/misc.h
@@ -381,6 +381,15 @@
 #define OPENTHREAD_CONFIG_POSIX_SETTINGS_PATH "tmp"
 #endif
 
+/**
+ * @def OPENTHREAD_CONFIG_PLATFORM_BOOTLOADER_MODE_ENABLE
+ *
+ * Define to 1 to enable support reset to bootloader mode.
+ */
+#ifndef OPENTHREAD_CONFIG_PLATFORM_BOOTLOADER_MODE_ENABLE
+#define OPENTHREAD_CONFIG_PLATFORM_BOOTLOADER_MODE_ENABLE 0
+#endif
+
 /**
  * @def OPENTHREAD_CONFIG_PLATFORM_FLASH_API_ENABLE
  *
@@ -590,6 +599,24 @@
 #define OPENTHREAD_CONFIG_PLATFORM_LOG_CRASH_DUMP_ENABLE 0
 #endif
 
+/**
+ * @def OPENTHREAD_ENABLE_VENDOR_EXTENSION
+ *
+ * Define to 1 to enable vendor extension support.
+ */
+#ifndef OPENTHREAD_ENABLE_VENDOR_EXTENSION
+#define OPENTHREAD_ENABLE_VENDOR_EXTENSION 0
+#endif
+
+/**
+ * @def OPENTHREAD_EXAMPLES_SIMULATION
+ *
+ * Define 1 to to enable simulation example support.
+ */
+#ifndef OPENTHREAD_EXAMPLES_SIMULATION
+#define OPENTHREAD_EXAMPLES_SIMULATION 0
+#endif
+
 /**
  * @}
  */
diff --git a/src/core/ftd.cmake b/src/core/ftd.cmake
index 074c4362c..2e16087cd 100644
--- a/src/core/ftd.cmake
+++ b/src/core/ftd.cmake
@@ -36,6 +36,7 @@ target_compile_definitions(openthread-ftd PRIVATE
 
 target_compile_options(openthread-ftd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-ftd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/core/mtd.cmake b/src/core/mtd.cmake
index ae8d9e3ef..ebef0d3b4 100644
--- a/src/core/mtd.cmake
+++ b/src/core/mtd.cmake
@@ -36,6 +36,7 @@ target_compile_definitions(openthread-mtd PRIVATE
 
 target_compile_options(openthread-mtd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-mtd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/core/radio.cmake b/src/core/radio.cmake
index a41605202..001e54b8b 100644
--- a/src/core/radio.cmake
+++ b/src/core/radio.cmake
@@ -37,6 +37,7 @@ target_compile_definitions(openthread-radio PRIVATE
 
 target_compile_options(openthread-radio PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-radio PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/ncp/ftd.cmake b/src/ncp/ftd.cmake
index 7255815f8..2b2a1c5d6 100644
--- a/src/ncp/ftd.cmake
+++ b/src/ncp/ftd.cmake
@@ -37,6 +37,7 @@ target_compile_definitions(openthread-ncp-ftd PRIVATE
 
 target_compile_options(openthread-ncp-ftd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-ncp-ftd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/ncp/mtd.cmake b/src/ncp/mtd.cmake
index b30a5759b..fb2955326 100644
--- a/src/ncp/mtd.cmake
+++ b/src/ncp/mtd.cmake
@@ -37,6 +37,7 @@ target_compile_definitions(openthread-ncp-mtd PRIVATE
 
 target_compile_options(openthread-ncp-mtd PRIVATE
     ${OT_CFLAGS}
+    -Wundef
 )
 
 target_include_directories(openthread-ncp-mtd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
diff --git a/src/ncp/ncp_config.h b/src/ncp/ncp_config.h
index 8fd34e07d..c60ee716f 100644
--- a/src/ncp/ncp_config.h
+++ b/src/ncp/ncp_config.h
@@ -207,4 +207,13 @@
 #define OPENTHREAD_ENABLE_NCP_VENDOR_HOOK 0
 #endif
 
+/**
+ * @def OPENTHREAD_ENABLE_NCP_SPINEL_ENCRYPTER
+ *
+ * Define to 1 to enable NCP spinel encrypter.
+ */
+#ifndef OPENTHREAD_ENABLE_NCP_SPINEL_ENCRYPTER
+#define OPENTHREAD_ENABLE_NCP_SPINEL_ENCRYPTER 0
+#endif
+
 #endif // CONFIG_NCP_H_