diff --git a/etc/gn/openthread.gni b/etc/gn/openthread.gni
index a64d83370..fe494b08e 100644
--- a/etc/gn/openthread.gni
+++ b/etc/gn/openthread.gni
@@ -231,6 +231,9 @@ if (openthread_enable_core_config_args) {
     # Enable builtin mbedtls management
     openthread_config_enable_builtin_mbedtls_management =
         openthread_external_mbedtls == ""
+
+    # Enable radio coexistence
+    openthread_config_coexistence_enable = false
   }
 }
 
diff --git a/src/core/BUILD.gn b/src/core/BUILD.gn
index 25cd1a1d9..bd837f508 100644
--- a/src/core/BUILD.gn
+++ b/src/core/BUILD.gn
@@ -264,6 +264,10 @@ if (openthread_enable_core_config_args) {
     if (openthread_config_otns_enable) {
       defines += [ "OPENTHREAD_CONFIG_OTNS_ENABLE=1" ]
     }
+
+    if (openthread_config_coexistence_enable) {
+      defines += [ "OPENTHREAD_CONFIG_PLATFORM_RADIO_COEX_ENABLE=1" ]
+    }
   }
 }