diff --git a/etc/cmake/options.cmake b/etc/cmake/options.cmake
index 4a5cddc69..6b59c9233 100644
--- a/etc/cmake/options.cmake
+++ b/etc/cmake/options.cmake
@@ -185,6 +185,11 @@ if(OT_PLATFORM_NETIF)
     list(APPEND OT_PRIVATE_DEFINES "OPENTHREAD_CONFIG_PLATFORM_NETIF_ENABLE=1")
 endif()
 
+option(OT_NCP_VENDOR_HOOK_SOURCE "Enable vendor hook for NCP")
+if(OT_NCP_VENDOR_HOOK_SOURCE)
+    list(APPEND OT_PRIVATE_DEFINES "OPENTHREAD_ENABLE_NCP_VENDOR_HOOK=1")
+endif()
+
 option(OT_PLATFORM_UDP "enable platform UDP support")
 if(OT_PLATFORM_UDP)
     list(APPEND OT_PRIVATE_DEFINES "OPENTHREAD_CONFIG_PLATFORM_UDP_ENABLE=1")
diff --git a/src/ncp/CMakeLists.txt b/src/ncp/CMakeLists.txt
index 01c6383ce..dc3836a7e 100644
--- a/src/ncp/CMakeLists.txt
+++ b/src/ncp/CMakeLists.txt
@@ -85,6 +85,12 @@ set(COMMON_SOURCES
     ncp_uart.cpp
 )
 
+if(DEFINED OT_NCP_VENDOR_HOOK_SOURCE)
+    if(NOT OT_NCP_VENDOR_HOOK_SOURCE STREQUAL "OFF")
+        list(APPEND COMMON_SOURCES ${OT_NCP_VENDOR_HOOK_SOURCE})
+    endif()
+endif()
+
 target_include_directories(openthread-ncp-ftd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
 target_include_directories(openthread-ncp-mtd PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})
 target_include_directories(openthread-rcp PUBLIC ${OT_PUBLIC_INCLUDES} PRIVATE ${COMMON_INCLUDES})