diff --git a/src/core/BUILD.gn b/src/core/BUILD.gn
index 9bb9ffd35..d79953aaa 100644
--- a/src/core/BUILD.gn
+++ b/src/core/BUILD.gn
@@ -30,6 +30,217 @@ import("../../etc/gn/openthread.gni")
 visibility = [ "../../*" ]
 
 if (openthread_enable_core_config_args) {
+  ot_bool_flags = [
+    {
+      macro = "OPENTHREAD_CONFIG_ANYCAST_LOCATOR_ENABLE"
+      value = openthread_config_anycast_locator_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_ASSERT_ENABLE"
+      value = openthread_config_assert_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_BACKBONE_ROUTER_ENABLE"
+      value = openthread_config_backbone_router_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_BLE_TCAT_ENABLE"
+      value = openthread_config_ble_tcat_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_BORDER_AGENT_ENABLE"
+      value = openthread_config_border_agent_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_BORDER_ROUTER_ENABLE"
+      value = openthread_config_border_router_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_BORDER_ROUTING_ENABLE"
+      value = openthread_config_border_routing_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_CHANNEL_MANAGER_ENABLE"
+      value = openthread_config_channel_manager_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_CHANNEL_MONITOR_ENABLE"
+      value = openthread_config_channel_monitor_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_COAP_API_ENABLE"
+      value = openthread_config_coap_api_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_COAP_OBSERVE_API_ENABLE"
+      value = openthread_config_coap_observe_api_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_COAP_SECURE_API_ENABLE"
+      value = openthread_config_coap_secure_api_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_COMMISSIONER_ENABLE"
+      value = openthread_config_commissioner_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DHCP6_CLIENT_ENABLE"
+      value = openthread_config_dhcp6_client_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DHCP6_SERVER_ENABLE"
+      value = openthread_config_dhcp6_server_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DIAG_ENABLE"
+      value = openthread_config_diag_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DNSSD_SERVER_ENABLE"
+      value = openthread_config_dnssd_server_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DNS_CLIENT_ENABLE"
+      value = openthread_config_dns_client_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_DUA_ENABLE"
+      value = openthread_config_dua_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_ECDSA_ENABLE"
+      value = openthread_config_ecdsa_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_HEAP_EXTERNAL_ENABLE"
+      value = openthread_config_heap_external_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_IP6_FRAGMENTATION_ENABLE"
+      value = openthread_config_ip6_fragmentation_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_IP6_SLAAC_ENABLE"
+      value = openthread_config_ip6_slaac_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_JAM_DETECTION_ENABLE"
+      value = openthread_config_jam_detection_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_JOINER_ENABLE"
+      value = openthread_config_joiner_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_LINK_RAW_ENABLE"
+      value = openthread_config_link_raw_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_LOG_LEVEL_DYNAMIC_ENABLE"
+      value = openthread_config_log_level_dynamic_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MAC_CSL_RECEIVER_ENABLE"
+      value = openthread_config_mac_csl_receiver_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MAC_FILTER_ENABLE"
+      value = openthread_config_mac_filter_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MESSAGE_USE_HEAP_ENABLE"
+      value = openthread_config_message_use_heap
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MLE_LINK_METRICS_INITIATOR_ENABLE"
+      value = openthread_config_link_metrics_initiator_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MLE_LINK_METRICS_SUBJECT_ENABLE"
+      value = openthread_config_link_metrics_subject_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MLE_LONG_ROUTES_ENABLE"
+      value = openthread_config_mle_long_routes_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MLR_ENABLE"
+      value = openthread_config_mlr_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_MULTIPLE_INSTANCE_ENABLE"
+      value = openthread_config_multiple_instance_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_OTNS_ENABLE"
+      value = openthread_config_otns_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_PING_SENDER_ENABLE"
+      value = openthread_config_ping_sender
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_PLATFORM_NETIF_ENABLE"
+      value = openthread_config_platform_netif_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_PLATFORM_RADIO_COEX_ENABLE"
+      value = openthread_config_coexistence_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_PLATFORM_UDP_ENABLE"
+      value = openthread_config_platform_udp_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_REFERENCE_DEVICE_ENABLE"
+      value = openthread_config_reference_device_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_SNTP_CLIENT_ENABLE"
+      value = openthread_config_sntp_client_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_SRP_CLIENT_ENABLE"
+      value = openthread_config_srp_client_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_SRP_SERVER_ENABLE"
+      value = openthread_config_srp_server_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_TCP_ENABLE"
+      value = openthread_config_tcp_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_TIME_SYNC_ENABLE"
+      value = openthread_config_time_sync_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_TMF_NETDATA_SERVICE_ENABLE"
+      value = openthread_config_tmf_netdata_service_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_TMF_NETDIAG_CLIENT_ENABLE"
+      value = openthread_config_tmf_netdiag_client_enable
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_UDP_FORWARD_ENABLE"
+      value = openthread_config_udp_forward_enable
+    },
+    {
+      macro = "OPENTHREAD_SETTINGS_RAM"
+      value = openthread_settings_ram
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_ENABLE_BUILTIN_MBEDTLS"
+      value = openthread_external_mbedtls == ""
+    },
+    {
+      macro = "OPENTHREAD_CONFIG_ENABLE_BUILTIN_MBEDTLS_MANAGEMENT"
+      value = openthread_external_mbedtls == "" && openthread_config_enable_builtin_mbedtls_management
+    },
+  ]
+
   config("core_config_args") {
     defines = []
 
@@ -69,64 +280,13 @@ if (openthread_enable_core_config_args) {
       defines += [ "OPENTHREAD_CONFIG_LOG_PREPEND_LEVEL=1" ]
     }
 
-    if (openthread_external_mbedtls != "") {
-      defines += [ "OPENTHREAD_CONFIG_ENABLE_BUILTIN_MBEDTLS=0" ]
-    } else {
-      defines += [ "OPENTHREAD_CONFIG_ENABLE_BUILTIN_MBEDTLS_MANAGEMENT=$openthread_config_enable_builtin_mbedtls_management" ]
+    foreach(flag, ot_bool_flags) {
+      if (flag.value) {
+        defines += [ "${flag.macro}=1" ]
+      } else {
+        defines += [ "${flag.macro}=0" ]
+      }
     }
-
-    defines += [
-      "OPENTHREAD_CONFIG_ANYCAST_LOCATOR_ENABLE=$openthread_config_anycast_locator_enable",
-      "OPENTHREAD_CONFIG_ASSERT_ENABLE=$openthread_config_assert_enable",
-      "OPENTHREAD_CONFIG_BACKBONE_ROUTER_ENABLE=$openthread_config_backbone_router_enable",
-      "OPENTHREAD_CONFIG_BLE_TCAT_ENABLE=$openthread_config_ble_tcat_enable",
-      "OPENTHREAD_CONFIG_BORDER_AGENT_ENABLE=$openthread_config_border_agent_enable",
-      "OPENTHREAD_CONFIG_BORDER_ROUTER_ENABLE=$openthread_config_border_router_enable",
-      "OPENTHREAD_CONFIG_BORDER_ROUTING_ENABLE=$openthread_config_border_routing_enable",
-      "OPENTHREAD_CONFIG_CHANNEL_MANAGER_ENABLE=$openthread_config_channel_manager_enable",
-      "OPENTHREAD_CONFIG_CHANNEL_MONITOR_ENABLE=$openthread_config_channel_monitor_enable",
-      "OPENTHREAD_CONFIG_COAP_API_ENABLE=$openthread_config_coap_api_enable",
-      "OPENTHREAD_CONFIG_COAP_OBSERVE_API_ENABLE=$openthread_config_coap_observe_api_enable",
-      "OPENTHREAD_CONFIG_COAP_SECURE_API_ENABLE=$openthread_config_coap_secure_api_enable",
-      "OPENTHREAD_CONFIG_COMMISSIONER_ENABLE=$openthread_config_commissioner_enable",
-      "OPENTHREAD_CONFIG_DHCP6_CLIENT_ENABLE=$openthread_config_dhcp6_client_enable",
-      "OPENTHREAD_CONFIG_DHCP6_SERVER_ENABLE=$openthread_config_dhcp6_server_enable",
-      "OPENTHREAD_CONFIG_DIAG_ENABLE=$openthread_config_diag_enable",
-      "OPENTHREAD_CONFIG_DNSSD_SERVER_ENABLE=$openthread_config_dnssd_server_enable",
-      "OPENTHREAD_CONFIG_DNS_CLIENT_ENABLE=$openthread_config_dns_client_enable",
-      "OPENTHREAD_CONFIG_DUA_ENABLE=$openthread_config_dua_enable",
-      "OPENTHREAD_CONFIG_ECDSA_ENABLE=$openthread_config_ecdsa_enable",
-      "OPENTHREAD_CONFIG_HEAP_EXTERNAL_ENABLE=$openthread_config_heap_external_enable",
-      "OPENTHREAD_CONFIG_IP6_FRAGMENTATION_ENABLE=$openthread_config_ip6_fragmentation_enable",
-      "OPENTHREAD_CONFIG_IP6_SLAAC_ENABLE=$openthread_config_ip6_slaac_enable",
-      "OPENTHREAD_CONFIG_JAM_DETECTION_ENABLE=$openthread_config_jam_detection_enable",
-      "OPENTHREAD_CONFIG_JOINER_ENABLE=$openthread_config_joiner_enable",
-      "OPENTHREAD_CONFIG_LINK_RAW_ENABLE=$openthread_config_link_raw_enable",
-      "OPENTHREAD_CONFIG_LOG_LEVEL_DYNAMIC_ENABLE=$openthread_config_log_level_dynamic_enable",
-      "OPENTHREAD_CONFIG_MAC_CSL_RECEIVER_ENABLE=$openthread_config_mac_csl_receiver_enable",
-      "OPENTHREAD_CONFIG_MAC_FILTER_ENABLE=$openthread_config_mac_filter_enable",
-      "OPENTHREAD_CONFIG_MESSAGE_USE_HEAP_ENABLE=$openthread_config_message_use_heap",
-      "OPENTHREAD_CONFIG_MLE_LINK_METRICS_INITIATOR_ENABLE=$openthread_config_link_metrics_initiator_enable",
-      "OPENTHREAD_CONFIG_MLE_LINK_METRICS_SUBJECT_ENABLE=$openthread_config_link_metrics_subject_enable",
-      "OPENTHREAD_CONFIG_MLE_LONG_ROUTES_ENABLE=$openthread_config_mle_long_routes_enable",
-      "OPENTHREAD_CONFIG_MLR_ENABLE=$openthread_config_mlr_enable",
-      "OPENTHREAD_CONFIG_MULTIPLE_INSTANCE_ENABLE=$openthread_config_multiple_instance_enable",
-      "OPENTHREAD_CONFIG_OTNS_ENABLE=$openthread_config_otns_enable",
-      "OPENTHREAD_CONFIG_PING_SENDER_ENABLE=$openthread_config_ping_sender",
-      "OPENTHREAD_CONFIG_PLATFORM_NETIF_ENABLE=$openthread_config_platform_netif_enable",
-      "OPENTHREAD_CONFIG_PLATFORM_RADIO_COEX_ENABLE=$openthread_config_coexistence_enable",
-      "OPENTHREAD_CONFIG_PLATFORM_UDP_ENABLE=$openthread_config_platform_udp_enable",
-      "OPENTHREAD_CONFIG_REFERENCE_DEVICE_ENABLE=$openthread_config_reference_device_enable",
-      "OPENTHREAD_CONFIG_SNTP_CLIENT_ENABLE=$openthread_config_sntp_client_enable",
-      "OPENTHREAD_CONFIG_SRP_CLIENT_ENABLE=$openthread_config_srp_client_enable",
-      "OPENTHREAD_CONFIG_SRP_SERVER_ENABLE=$openthread_config_srp_server_enable",
-      "OPENTHREAD_CONFIG_TCP_ENABLE=${openthread_config_tcp_enable}",
-      "OPENTHREAD_CONFIG_TIME_SYNC_ENABLE=$openthread_config_time_sync_enable",
-      "OPENTHREAD_CONFIG_TMF_NETDATA_SERVICE_ENABLE=$openthread_config_tmf_netdata_service_enable",
-      "OPENTHREAD_CONFIG_TMF_NETDIAG_CLIENT_ENABLE=$openthread_config_tmf_netdiag_client_enable",
-      "OPENTHREAD_CONFIG_UDP_FORWARD_ENABLE=$openthread_config_udp_forward_enable",
-      "OPENTHREAD_SETTINGS_RAM=$openthread_settings_ram",
-    ]
   }
 }