diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 65a587a07..91156b57f 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -376,33 +376,3 @@ jobs:
       run: |
         script/check-posix-build
         script/check-simulation-build
-
-  android-ndk:
-    name: android-ndk
-    runs-on: ubuntu-24.04
-    container:
-      image: openthread/environment
-    steps:
-    - name: Harden Runner
-      uses: step-security/harden-runner@5ef0c079ce82195b2a36a210272d6b661572d83e # v2.14.2
-      with:
-        egress-policy: audit # TODO: change to 'egress-policy: block' after couple of runs
-
-    - uses: actions/checkout@08c6903cd8c0fde910a37f88322edcfb5dd907a8 # v5.0.0
-      with:
-        submodules: recursive
-    - name: Install unzip
-      run: apt update && apt install -y unzip
-    - name: Setup NDK
-      id: setup-ndk
-      uses: nttld/setup-ndk@afb4c9964b521afb97c864b7d40b11e6911bd410 # v1.5.0
-      with:
-        ndk-version: r25c
-        local-cache: true
-
-    - name: Build
-      env:
-        NDK: ${{ steps.setup-ndk.outputs.ndk-path }}
-      run: |
-        rm -rf build/ && OT_CMAKE_NINJA_TARGET="ot-daemon ot-ctl" script/cmake-build android-ndk
-        rm -rf build/ && OT_CMAKE_NINJA_TARGET="ot-cli" script/cmake-build android-ndk
diff --git a/script/cmake-build b/script/cmake-build
index 34ec20cb3..e04efe63c 100755
--- a/script/cmake-build
+++ b/script/cmake-build
@@ -67,7 +67,7 @@ OT_CMAKE_NINJA_TARGET=${OT_CMAKE_NINJA_TARGET-}
 OT_SRCDIR="$(cd "$(dirname "$0")"/.. && pwd)"
 readonly OT_SRCDIR
 
-OT_PLATFORMS=(simulation posix android-ndk)
+OT_PLATFORMS=(simulation posix)
 readonly OT_PLATFORMS
 
 OT_CLEAN_INTERMEDIATES="${OT_CLEAN_INTERMEDIATES-${GITHUB_ACTION-}}"
@@ -166,58 +166,6 @@ main()
     )
 
     case "${platform}" in
-        android-ndk)
-            if [ -z "${NDK-}" ]; then
-                echo "
-The 'NDK' environment variable needs to point to the Android NDK toolchain.
-Please ensure the NDK is downloaded and extracted then try to run this script again
-
-For example:
-    NDK=/opt/android-ndk-r25c ./script/cmake-build-android
-
-You can download the NDK at https://developer.android.com/ndk/downloads
-
-            "
-                exit 1
-            fi
-
-            NDK_CMAKE_TOOLCHAIN_FILE="${NDK?}/build/cmake/android.toolchain.cmake"
-            if [ ! -f "${NDK_CMAKE_TOOLCHAIN_FILE}" ]; then
-                echo "
-Could not fild the Android NDK CMake toolchain file
-- NDK=${NDK}
-- NDK_CMAKE_TOOLCHAIN_FILE=${NDK_CMAKE_TOOLCHAIN_FILE}
-
-            "
-                exit 2
-            fi
-            local_options+=(
-                "-DOT_LOG_OUTPUT=PLATFORM_DEFINED"
-
-                # Add Android NDK flags
-                "-DOT_ANDROID_NDK=1"
-                "-DCMAKE_TOOLCHAIN_FILE=${NDK?}/build/cmake/android.toolchain.cmake"
-
-                # Android API needs to be >= android-24 for `getifsaddrs()`
-                "-DANDROID_PLATFORM=android-24"
-
-                # Store thread settings in the CWD when executing ot-cli or ot-daemon
-                '-DOT_POSIX_SETTINGS_PATH="./thread"'
-            )
-
-            # Rewrite platform to posix
-            platform="posix"
-
-            # Check if OT_DAEMON or OT_APP_CLI flags are needed
-            if [[ ${OT_CMAKE_NINJA_TARGET[*]} =~ "ot-daemon" ]] || [[ ${OT_CMAKE_NINJA_TARGET[*]} =~ "ot-ctl" ]]; then
-                local_options+=("-DOT_DAEMON=ON")
-            elif [[ ${OT_CMAKE_NINJA_TARGET[*]} =~ "ot-cli" ]]; then
-                local_options+=("-DOT_APP_CLI=ON")
-            fi
-
-            options+=("${local_options[@]}")
-            ;;
-
         posix)
             local_options+=(
                 "-DOT_TCP=OFF"