diff --git a/src/posix/platform/radio_spinel.cpp b/src/posix/platform/radio_spinel.cpp
index 633cf9596..c6c4e6531 100644
--- a/src/posix/platform/radio_spinel.cpp
+++ b/src/posix/platform/radio_spinel.cpp
@@ -459,7 +459,7 @@ static int OpenFile(const char *aFile, const char *aConfig)
             break;
         }
 
-        VerifyOrExit((rval = cfsetispeed(&tios, speed)) == 0, perror("cfsetispeed"));
+        VerifyOrExit((rval = cfsetspeed(&tios, speed)) == 0, perror("cfsetspeed"));
         VerifyOrExit((rval = tcsetattr(fd, TCSANOW, &tios)) == 0, perror("tcsetattr"));
         VerifyOrExit((rval = tcflush(fd, TCIOFLUSH)) == 0);
     }