diff --git a/CMakeLists.txt b/CMakeLists.txt
index 642332f5e..7a31b16d3 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -40,6 +40,9 @@ set(OT_EXTERNAL_MBEDTLS "" CACHE STRING "Specify external mbedtls library")
 option(OT_MBEDTLS_THREADING "enable mbedtls threading" OFF)
 
 add_library(ot-config INTERFACE)
+add_library(ot-config-ftd INTERFACE)
+add_library(ot-config-mtd INTERFACE)
+add_library(ot-config-radio INTERFACE)
 set(CMAKE_CXX_EXTENSIONS OFF)
 set(CMAKE_CXX_STANDARD 11)
 set(CMAKE_C_STANDARD 99)
diff --git a/examples/apps/cli/ftd.cmake b/examples/apps/cli/ftd.cmake
index f5a2870f8..b8aac6e56 100644
--- a/examples/apps/cli/ftd.cmake
+++ b/examples/apps/cli/ftd.cmake
@@ -44,6 +44,7 @@ target_link_libraries(ot-cli-ftd PRIVATE
     ${OT_PLATFORM_LIB_FTD}
     openthread-cli-ftd
     ${OT_MBEDTLS}
+    ot-config-ftd
     ot-config
 )
 
diff --git a/examples/apps/cli/mtd.cmake b/examples/apps/cli/mtd.cmake
index 7b71883bb..df1729673 100644
--- a/examples/apps/cli/mtd.cmake
+++ b/examples/apps/cli/mtd.cmake
@@ -44,6 +44,7 @@ target_link_libraries(ot-cli-mtd PRIVATE
     ${OT_PLATFORM_LIB_MTD}
     openthread-cli-mtd
     ${OT_MBEDTLS}
+    ot-config-mtd
     ot-config
 )
 
diff --git a/examples/apps/cli/radio.cmake b/examples/apps/cli/radio.cmake
index 4302adca5..715c0f687 100644
--- a/examples/apps/cli/radio.cmake
+++ b/examples/apps/cli/radio.cmake
@@ -48,6 +48,7 @@ target_link_libraries(ot-cli-radio PRIVATE
     ${OT_PLATFORM_LIB_RCP}
     openthread-cli-radio
     ${OT_MBEDTLS_RCP}
+    ot-config-radio
     ot-config
 )
 
diff --git a/examples/apps/ncp/ftd.cmake b/examples/apps/ncp/ftd.cmake
index c7d0bbf5d..353b21bac 100644
--- a/examples/apps/ncp/ftd.cmake
+++ b/examples/apps/ncp/ftd.cmake
@@ -44,6 +44,7 @@ target_link_libraries(ot-ncp-ftd PRIVATE
     ${OT_PLATFORM_LIB_FTD}
     openthread-ncp-ftd
     ${OT_MBEDTLS}
+    ot-config-ftd
     ot-config
 )
 
diff --git a/examples/apps/ncp/mtd.cmake b/examples/apps/ncp/mtd.cmake
index 61380c3b5..6a548ee9a 100644
--- a/examples/apps/ncp/mtd.cmake
+++ b/examples/apps/ncp/mtd.cmake
@@ -44,6 +44,7 @@ target_link_libraries(ot-ncp-mtd PRIVATE
     ${OT_PLATFORM_LIB_MTD}
     openthread-ncp-mtd
     ${OT_MBEDTLS}
+    ot-config-mtd
     ot-config
 )
 
diff --git a/examples/apps/ncp/rcp.cmake b/examples/apps/ncp/rcp.cmake
index 7ba3b9725..40334c339 100644
--- a/examples/apps/ncp/rcp.cmake
+++ b/examples/apps/ncp/rcp.cmake
@@ -43,6 +43,7 @@ target_link_libraries(ot-rcp PRIVATE
     openthread-radio
     ${OT_PLATFORM_LIB_RCP}
     openthread-rcp
+    ot-config-radio
     ot-config
 )
 
diff --git a/src/cli/ftd.cmake b/src/cli/ftd.cmake
index a101da342..22f1e11f6 100644
--- a/src/cli/ftd.cmake
+++ b/src/cli/ftd.cmake
@@ -46,5 +46,6 @@ target_link_libraries(openthread-cli-ftd
         openthread-ftd
     PRIVATE
         ${OT_MBEDTLS}
+        ot-config-ftd
         ot-config
 )
diff --git a/src/cli/mtd.cmake b/src/cli/mtd.cmake
index c8c42305d..3a875c39d 100644
--- a/src/cli/mtd.cmake
+++ b/src/cli/mtd.cmake
@@ -46,5 +46,6 @@ target_link_libraries(openthread-cli-mtd
         openthread-mtd
     PRIVATE
         ${OT_MBEDTLS}
+        ot-config-mtd
         ot-config
 )
diff --git a/src/cli/radio.cmake b/src/cli/radio.cmake
index 3e7354aa6..6fa0b9144 100644
--- a/src/cli/radio.cmake
+++ b/src/cli/radio.cmake
@@ -55,5 +55,6 @@ target_link_libraries(openthread-cli-radio
         openthread-radio
     PRIVATE
         ${OT_MBEDTLS_RCP}
+        ot-config-radio
         ot-config
 )
diff --git a/src/core/ftd.cmake b/src/core/ftd.cmake
index 8bf3e0e6a..928a2b4c3 100644
--- a/src/core/ftd.cmake
+++ b/src/core/ftd.cmake
@@ -43,6 +43,7 @@ target_sources(openthread-ftd PRIVATE ${COMMON_SOURCES})
 target_link_libraries(openthread-ftd
     PRIVATE
         ${OT_MBEDTLS}
+        ot-config-ftd
         ot-config
 )
 
diff --git a/src/core/mtd.cmake b/src/core/mtd.cmake
index feec81e41..9857a734b 100644
--- a/src/core/mtd.cmake
+++ b/src/core/mtd.cmake
@@ -43,6 +43,7 @@ target_sources(openthread-mtd PRIVATE ${COMMON_SOURCES})
 target_link_libraries(openthread-mtd
     PRIVATE
         ${OT_MBEDTLS}
+        ot-config-mtd
         ot-config
 )
 
diff --git a/src/core/radio.cmake b/src/core/radio.cmake
index f70a8dd36..95ae91533 100644
--- a/src/core/radio.cmake
+++ b/src/core/radio.cmake
@@ -54,5 +54,6 @@ endif()
 target_link_libraries(openthread-radio
     PRIVATE
         ${OT_MBEDTLS_RCP}
+        ot-config-radio
         ot-config
 )
diff --git a/src/core/radio_cli.cmake b/src/core/radio_cli.cmake
index b4e26fe18..31e7b6dae 100644
--- a/src/core/radio_cli.cmake
+++ b/src/core/radio_cli.cmake
@@ -54,5 +54,6 @@ endif()
 target_link_libraries(openthread-radio-cli
     PRIVATE
         ${OT_MBEDTLS_RCP}
+        ot-config-radio
         ot-config
 )
diff --git a/src/lib/spinel/CMakeLists.txt b/src/lib/spinel/CMakeLists.txt
index 85114f78f..5c01ec30c 100644
--- a/src/lib/spinel/CMakeLists.txt
+++ b/src/lib/spinel/CMakeLists.txt
@@ -67,5 +67,14 @@ target_include_directories(openthread-spinel-rcp PUBLIC ${OT_PUBLIC_INCLUDES} PR
 target_sources(openthread-spinel-ncp PRIVATE ${COMMON_SOURCES})
 target_sources(openthread-spinel-rcp PRIVATE ${COMMON_SOURCES})
 
-target_link_libraries(openthread-spinel-ncp PRIVATE ot-config)
-target_link_libraries(openthread-spinel-rcp PRIVATE ot-config)
+target_link_libraries(openthread-spinel-ncp
+    PRIVATE
+        ot-config-ftd
+        ot-config
+)
+
+target_link_libraries(openthread-spinel-rcp
+    PRIVATE
+        ot-config-radio
+        ot-config
+)
diff --git a/src/ncp/ftd.cmake b/src/ncp/ftd.cmake
index 4ba31307d..43b5f4f80 100644
--- a/src/ncp/ftd.cmake
+++ b/src/ncp/ftd.cmake
@@ -49,5 +49,6 @@ target_link_libraries(openthread-ncp-ftd
         ${OT_MBEDTLS}
         openthread-hdlc
         openthread-spinel-ncp
+        ot-config-ftd
         ot-config
 )
diff --git a/src/ncp/mtd.cmake b/src/ncp/mtd.cmake
index e1ceb6f8a..6d8de8e14 100644
--- a/src/ncp/mtd.cmake
+++ b/src/ncp/mtd.cmake
@@ -49,5 +49,6 @@ target_link_libraries(openthread-ncp-mtd
         ${OT_MBEDTLS}
         openthread-hdlc
         openthread-spinel-ncp
+        ot-config-mtd
         ot-config
 )
diff --git a/src/ncp/radio.cmake b/src/ncp/radio.cmake
index 427e7b5da..3b3122f48 100644
--- a/src/ncp/radio.cmake
+++ b/src/ncp/radio.cmake
@@ -49,5 +49,6 @@ target_link_libraries(openthread-rcp
     PRIVATE
         openthread-hdlc
         openthread-spinel-rcp
+        ot-config-radio
         ot-config
 )
diff --git a/src/posix/cli.cmake b/src/posix/cli.cmake
index e9b2e1033..4354374d2 100644
--- a/src/posix/cli.cmake
+++ b/src/posix/cli.cmake
@@ -53,6 +53,7 @@ target_link_libraries(ot-cli
     openthread-spinel-rcp
     ${OT_MBEDTLS}
     ${READLINE_LINK_LIBRARIES}
+    ot-config-ftd
     ot-config
 )
 
diff --git a/src/posix/daemon.cmake b/src/posix/daemon.cmake
index 7116a4a2b..cf2c7b7d9 100644
--- a/src/posix/daemon.cmake
+++ b/src/posix/daemon.cmake
@@ -45,6 +45,7 @@ target_link_libraries(ot-daemon PRIVATE
     openthread-spinel-rcp
     ${OT_MBEDTLS}
     ot-posix-config
+    ot-config-ftd
     ot-config
 )
 
diff --git a/src/posix/platform/CMakeLists.txt b/src/posix/platform/CMakeLists.txt
index 541dbb211..1f9081747 100644
--- a/src/posix/platform/CMakeLists.txt
+++ b/src/posix/platform/CMakeLists.txt
@@ -121,6 +121,7 @@ target_link_libraries(openthread-posix
         openthread-platform
     PRIVATE
         openthread-url
+        ot-config-ftd
         ot-config
         ot-posix-config
         util