diff --git a/.github/workflows/simulation-1.1.yml b/.github/workflows/simulation-1.1.yml
index 5889015ec..02d96fb09 100644
--- a/.github/workflows/simulation-1.1.yml
+++ b/.github/workflows/simulation-1.1.yml
@@ -372,6 +372,7 @@ jobs:
       REFERENCE_DEVICE: 1
       THREAD_VERSION: 1.1
       VIRTUAL_TIME: 1
+      CXXFLAGS: "-DOPENTHREAD_CONFIG_LOG_PREPEND_UPTIME=0"
     steps:
     - uses: actions/checkout@v2
       with:
diff --git a/examples/platforms/simulation/openthread-core-simulation-config.h b/examples/platforms/simulation/openthread-core-simulation-config.h
index d9355bc37..f6f953b1e 100644
--- a/examples/platforms/simulation/openthread-core-simulation-config.h
+++ b/examples/platforms/simulation/openthread-core-simulation-config.h
@@ -212,4 +212,24 @@
 #define OPENTHREAD_CONFIG_MLE_INFORM_PREVIOUS_PARENT_ON_REATTACH 1
 #endif
 
+/**
+ * @def OPENTHREAD_CONFIG_UPTIME_ENABLE
+ *
+ * Define to 1 to enable tracking the uptime of OpenThread instance.
+ *
+ */
+#ifndef OPENTHREAD_CONFIG_UPTIME_ENABLE
+#define OPENTHREAD_CONFIG_UPTIME_ENABLE 1
+#endif
+
+/**
+ * @def OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME
+ *
+ * Define as 1 to prepend the current uptime to all log messages.
+ *
+ */
+#ifndef OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME
+#define OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME 1
+#endif
+
 #endif // OPENTHREAD_CORE_SIMULATION_CONFIG_H_
diff --git a/src/posix/platform/openthread-core-posix-config.h b/src/posix/platform/openthread-core-posix-config.h
index d1ceb9208..a9754656e 100644
--- a/src/posix/platform/openthread-core-posix-config.h
+++ b/src/posix/platform/openthread-core-posix-config.h
@@ -267,4 +267,24 @@
 #define OPENTHREAD_CONFIG_CLI_UART_RX_BUFFER_SIZE 640
 #endif
 
+/**
+ * @def OPENTHREAD_CONFIG_UPTIME_ENABLE
+ *
+ * Define to 1 to enable tracking the uptime of OpenThread instance.
+ *
+ */
+#ifndef OPENTHREAD_CONFIG_UPTIME_ENABLE
+#define OPENTHREAD_CONFIG_UPTIME_ENABLE 1
+#endif
+
+/**
+ * @def OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME
+ *
+ * Define as 1 to prepend the current uptime to all log messages.
+ *
+ */
+#ifndef OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME
+#define OPENTHREAD_CONFIG_LOG_PREPEND_UPTIME 1
+#endif
+
 #endif // OPENTHREAD_CORE_POSIX_CONFIG_H_