diff --git a/examples/platforms/nrf52840/alarm.c b/examples/platforms/nrf52840/alarm.c
index 4993b607a..4ef93236a 100644
--- a/examples/platforms/nrf52840/alarm.c
+++ b/examples/platforms/nrf52840/alarm.c
@@ -265,7 +265,6 @@ static void AlarmStop(AlarmIndex aIndex)
     sTimerData[aIndex].mFireAlarm = false;
 }
 
-
 void nrf5AlarmInit(void)
 {
     sTimeOffset.mMs = 0;
@@ -298,6 +297,28 @@ void nrf5AlarmInit(void)
     nrf_rtc_task_trigger(RTC_INSTANCE, NRF_RTC_TASK_START);
 }
 
+void nrf5AlarmDeinit(void)
+{
+    nrf_rtc_task_trigger(RTC_INSTANCE, NRF_RTC_TASK_STOP);
+
+    for (uint32_t i = 0; i < kNumTimers; i++)
+    {
+        nrf_rtc_event_clear(RTC_INSTANCE, sChannelData[i].mCompareEvent);
+        nrf_rtc_event_disable(RTC_INSTANCE, sChannelData[i].mCompareEventMask);
+        nrf_rtc_int_disable(RTC_INSTANCE, sChannelData[i].mCompareInt);
+    }
+
+    nrf_rtc_int_disable(RTC_INSTANCE, NRF_RTC_INT_OVERFLOW_MASK);
+    nrf_rtc_event_disable(RTC_INSTANCE, RTC_EVTEN_OVRFLW_Msk);
+    nrf_rtc_event_clear(RTC_INSTANCE, NRF_RTC_EVENT_OVERFLOW);
+
+    NVIC_DisableIRQ(RTC_IRQN);
+    NVIC_ClearPendingIRQ(RTC_IRQN);
+    NVIC_SetPriority(RTC_IRQN, 0);
+
+    nrf_drv_clock_lfclk_release();
+}
+
 void nrf5AlarmProcess(otInstance *aInstance)
 {
     if (sTimerData[kMsTimer].mFireAlarm)
diff --git a/examples/platforms/nrf52840/logging.c b/examples/platforms/nrf52840/logging.c
index a6196e42c..2243c1a04 100644
--- a/examples/platforms/nrf52840/logging.c
+++ b/examples/platforms/nrf52840/logging.c
@@ -136,6 +136,11 @@ exit:
     return;
 }
 
+void nrf5LogDeinit()
+{
+    sLogInitialized = false;
+}
+
 void otPlatLog(otLogLevel aLogLevel, otLogRegion aLogRegion,
                const char *aFormat, ...)
 {
diff --git a/examples/platforms/nrf52840/misc.c b/examples/platforms/nrf52840/misc.c
index 61a4ff83d..bd026d72c 100644
--- a/examples/platforms/nrf52840/misc.c
+++ b/examples/platforms/nrf52840/misc.c
@@ -38,6 +38,11 @@ __WEAK void nrf5CryptoInit(void)
     // This function is defined as weak so it could be overridden with external implementation.
 }
 
+__WEAK void nrf5CryptoDeinit(void)
+{
+    // This function is defined as weak so it could be overridden with external implementation.
+}
+
 void nrf5MiscInit(void)
 {
     // Read the reason of last reset.
@@ -47,6 +52,11 @@ void nrf5MiscInit(void)
     NRF_POWER->RESETREAS = 0xFFFFFFFF;
 }
 
+void nrf5MiscDeinit(void)
+{
+    // Intentionally empty.
+}
+
 void otPlatReset(otInstance *aInstance)
 {
     (void)aInstance;
diff --git a/examples/platforms/nrf52840/platform-nrf5.h b/examples/platforms/nrf52840/platform-nrf5.h
index e1cdcd7f0..9af305ca2 100644
--- a/examples/platforms/nrf52840/platform-nrf5.h
+++ b/examples/platforms/nrf52840/platform-nrf5.h
@@ -47,6 +47,12 @@
  */
 void nrf5UartInit(void);
 
+/**
+ * Deinitialization of UART driver.
+ *
+ */
+void nrf5UartDeinit(void);
+
 /**
  * This function performs UART driver processing.
  *
@@ -59,6 +65,12 @@ void nrf5UartProcess(void);
  */
 void nrf5AlarmInit(void);
 
+/**
+ * Deinitialization of Alarm driver.
+ *
+ */
+void nrf5AlarmDeinit(void);
+
 /**
  * Function for processing Alarm.
  *
@@ -71,12 +83,24 @@ void nrf5AlarmProcess(otInstance *aInstance);
  */
 void nrf5RandomInit(void);
 
+/**
+ * Deinitialization of Random Number Generator.
+ *
+ */
+void nrf5RandomDeinit(void);
+
 /**
  * Initialization of Logger driver.
  *
  */
 void nrf5LogInit(void);
 
+/**
+ * Deinitialization of Logger driver.
+ *
+ */
+void nrf5LogDeinit(void);
+
 /**
  * Initialization of Misc module.
  *
@@ -84,11 +108,23 @@ void nrf5LogInit(void);
 void nrf5MiscInit(void);
 
 /**
- * Initialization of Radio peripheral.
+ * Deinitialization of Misc module.
+ *
+ */
+void nrf5MiscDeinit(void);
+
+/**
+ * Initialization of Radio driver.
  *
  */
 void nrf5RadioInit(void);
 
+/**
+ * Deinitialization of Radio driver.
+ *
+ */
+void nrf5RadioDeinit(void);
+
 /**
  * Function for processing Radio.
  *
@@ -101,4 +137,10 @@ void nrf5RadioProcess(otInstance *aInstance);
  */
 void nrf5CryptoInit(void);
 
+/**
+ * Deinitialization of hardware crypto engine.
+ *
+ */
+void nrf5CryptoDeinit(void);
+
 #endif  // PLATFORM_NRF5_H_
diff --git a/examples/platforms/nrf52840/platform.c b/examples/platforms/nrf52840/platform.c
index f9fc5fbdd..3f2357331 100644
--- a/examples/platforms/nrf52840/platform.c
+++ b/examples/platforms/nrf52840/platform.c
@@ -59,6 +59,19 @@ void PlatformInit(int argc, char *argv[])
 #endif
 }
 
+void PlatformDeinit(void)
+{
+#if (OPENTHREAD_ENABLE_DEFAULT_LOGGING == 0)
+    nrf5LogDeinit();
+#endif
+    nrf5RadioDeinit();
+    nrf5CryptoDeinit();
+    nrf5MiscDeinit();
+    nrf5UartDeinit();
+    nrf5RandomDeinit();
+    nrf5AlarmDeinit();
+}
+
 void PlatformProcessDrivers(otInstance *aInstance)
 {
     nrf5AlarmProcess(aInstance);
diff --git a/examples/platforms/nrf52840/radio.c b/examples/platforms/nrf52840/radio.c
index d0becf6e7..54495167c 100644
--- a/examples/platforms/nrf52840/radio.c
+++ b/examples/platforms/nrf52840/radio.c
@@ -188,6 +188,11 @@ void nrf5RadioInit(void)
     nrf_drv_radio802154_init();
 }
 
+void nrf5RadioDeinit(void)
+{
+    nrf_drv_radio802154_deinit();
+}
+
 PhyState otPlatRadioGetState(otInstance *aInstance)
 {
     (void) aInstance;
diff --git a/examples/platforms/nrf52840/random.c b/examples/platforms/nrf52840/random.c
index cbf852eb1..04254f414 100644
--- a/examples/platforms/nrf52840/random.c
+++ b/examples/platforms/nrf52840/random.c
@@ -136,6 +136,15 @@ void nrf5RandomInit(void)
     srand(seed);
 }
 
+void nrf5RandomDeinit(void)
+{
+    generatorStop();
+
+    NVIC_DisableIRQ(RNG_IRQn);
+    NVIC_ClearPendingIRQ(RNG_IRQn);
+    NVIC_SetPriority(RNG_IRQn, 0);
+}
+
 uint32_t otPlatRandomGet(void)
 {
     return (uint32_t)rand();
diff --git a/examples/platforms/nrf52840/uart.c b/examples/platforms/nrf52840/uart.c
index 9176de192..15bb96206 100644
--- a/examples/platforms/nrf52840/uart.c
+++ b/examples/platforms/nrf52840/uart.c
@@ -177,6 +177,20 @@ void nrf5UartInit(void)
     NVIC_EnableIRQ(UART_IRQN);
 }
 
+void nrf5UartDeinit(void)
+{
+    // Disable NVIC interrupt.
+    NVIC_DisableIRQ(UART_IRQN);
+    NVIC_ClearPendingIRQ(UART_IRQN);
+    NVIC_SetPriority(UART_IRQN, 0);
+
+    // Disable interrupts for TX.
+    nrf_uart_int_disable(UART_INSTANCE, NRF_UART_INT_MASK_TXDRDY);
+
+    // Disable interrupts for RX.
+    nrf_uart_int_disable(UART_INSTANCE, NRF_UART_INT_MASK_RXDRDY | NRF_UART_INT_MASK_ERROR);
+}
+
 ThreadError otPlatUartEnable(void)
 {
     // Start HFCLK
@@ -193,21 +207,12 @@ ThreadError otPlatUartEnable(void)
 
 ThreadError otPlatUartDisable(void)
 {
-    // Release HF clock.
-    nrf_drv_clock_hfclk_release();
-
-    // Disable interrupts for TX.
-    nrf_uart_int_disable(UART_INSTANCE, NRF_UART_INT_MASK_TXDRDY);
-
-    // Disable interrupts for RX.
-    nrf_uart_int_disable(UART_INSTANCE, NRF_UART_INT_MASK_RXDRDY | NRF_UART_INT_MASK_ERROR);
-
-    // Disable NVIC interrupt.
-    NVIC_DisableIRQ(UART_IRQN);
-
     // Disable UART instance.
     nrf_uart_disable(UART_INSTANCE);
 
+    // Release HF clock.
+    nrf_drv_clock_hfclk_release();
+
     return kThreadError_None;
 }
 
diff --git a/include/openthread/platform/platform.h b/include/openthread/platform/platform.h
index 744c1831c..d51c408fe 100644
--- a/include/openthread/platform/platform.h
+++ b/include/openthread/platform/platform.h
@@ -47,6 +47,12 @@ extern "C" {
  */
 void PlatformInit(int argc, char *argv[]);
 
+/**
+ * This function performs all platform-specific deinitialization.
+ *
+ */
+void PlatformDeinit(void);
+
 /**
  * This function performs all platform-specific processing.
  *
diff --git a/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.c b/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.c
index 53b04deaa..fb9192e3a 100644
--- a/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.c
+++ b/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.c
@@ -244,6 +244,13 @@ static void critical_section_exit(void)
 }
 
 
+// Reset radio peripheral
+static void nrf_radio_reset(void)
+{
+    nrf_radio_power_set(false);
+    nrf_radio_power_set(true);
+}
+
 // Set radio state
 static inline void state_set(radio_state_t state)
 {
@@ -311,6 +318,13 @@ static void irq_init(void)
     NVIC_EnableIRQ(RADIO_IRQn);
 }
 
+static void irq_deinit(void)
+{
+    NVIC_DisableIRQ(RADIO_IRQn);
+    NVIC_ClearPendingIRQ(RADIO_IRQn);
+    NVIC_SetPriority(RADIO_IRQn, 0);
+}
+
 // Set radio channel
 static void channel_set(uint8_t channel)
 {
@@ -850,9 +864,7 @@ static void radio_reset(void)
 {
     uint8_t channel = channel_get();
 
-    nrf_radio_power_set(false);
-    nrf_radio_power_set(true);
-
+    nrf_radio_reset();
     nrf_radio_init();
 
     channel_set(channel);
@@ -919,10 +931,17 @@ void nrf_drv_radio802154_init(void)
 {
     data_init();
 
+    nrf_radio_reset();
     nrf_radio_init();
     irq_init();
 }
 
+void nrf_drv_radio802154_deinit(void)
+{
+    nrf_radio_reset();
+    irq_deinit();
+}
+
 nrf_drv_radio802154_state_t nrf_drv_radio802154_state_get(void)
 {
     switch (m_state)
diff --git a/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.h b/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.h
index 34c546735..8e0ec86b6 100644
--- a/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.h
+++ b/third_party/NordicSemiconductor/drivers/nrf_drv_radio802154.h
@@ -64,6 +64,13 @@ typedef enum
  */
 void nrf_drv_radio802154_init(void);
 
+/**
+ * @brief Deinitialize 802.15.4 driver.
+ *
+ * Deinitialize radio peripheral and reset it to the default state.
+ */
+void nrf_drv_radio802154_deinit(void);
+
 /**
  * @brief Get channel on which the radio operates right now.
  */