diff --git a/tests/fuzz/radio-one-node.cpp b/tests/fuzz/radio-one-node.cpp
index 6458e9bd2..2991f464e 100644
--- a/tests/fuzz/radio-one-node.cpp
+++ b/tests/fuzz/radio-one-node.cpp
@@ -96,6 +96,11 @@ extern "C" int LLVMFuzzerTestOneInput(const uint8_t *data, size_t size)
 
     node.GetInstance().SetLogLevel(kLogLevelInfo);
 
+    node.GetInstance().Get<Srp::Server>().SetAutoEnableMode(true);
+    node.GetInstance().Get<BorderRouter::RoutingManager>().SetDhcp6PdEnabled(true);
+    node.GetInstance().Get<BorderRouter::RoutingManager>().SetNat64PrefixManagerEnabled(true);
+    node.GetInstance().Get<Nat64::Translator>().SetEnabled(true);
+
     Log("---------------------------------------------------------------------------------------");
     Log("Form network");
 
diff --git a/tests/nexus/openthread-core-nexus-config.h b/tests/nexus/openthread-core-nexus-config.h
index 39fbb0445..def70f8e0 100644
--- a/tests/nexus/openthread-core-nexus-config.h
+++ b/tests/nexus/openthread-core-nexus-config.h
@@ -47,9 +47,10 @@
 #define OPENTHREAD_CONFIG_BORDER_AGENT_EPHEMERAL_KEY_ENABLE 1
 #define OPENTHREAD_CONFIG_BORDER_AGENT_ID_ENABLE 1
 #define OPENTHREAD_CONFIG_BORDER_ROUTER_ENABLE 1
-#define OPENTHREAD_CONFIG_BORDER_ROUTING_DHCP6_PD_ENABLE 0
-#define OPENTHREAD_CONFIG_BORDER_ROUTING_ENABLE 0
-#define OPENTHREAD_CONFIG_BORDER_ROUTING_USE_HEAP_ENABLE 0
+#define OPENTHREAD_CONFIG_BORDER_ROUTING_DHCP6_PD_ENABLE 1
+#define OPENTHREAD_CONFIG_BORDER_ROUTING_ENABLE 1
+#define OPENTHREAD_CONFIG_BORDER_ROUTING_MOCK_PLAT_APIS_ENABLE 1
+#define OPENTHREAD_CONFIG_BORDER_ROUTING_USE_HEAP_ENABLE 1
 #define OPENTHREAD_CONFIG_CHANNEL_MANAGER_ENABLE 1
 #define OPENTHREAD_CONFIG_CHANNEL_MONITOR_ENABLE 1
 #define OPENTHREAD_CONFIG_COAP_API_ENABLE 1
@@ -97,7 +98,8 @@
 #define OPENTHREAD_CONFIG_MULTICAST_DNS_ENABLE 1
 #define OPENTHREAD_CONFIG_MULTICAST_DNS_ENTRY_ITERATION_API_ENABLE 1
 #define OPENTHREAD_CONFIG_MULTICAST_DNS_PUBLIC_API_ENABLE 1
-#define OPENTHREAD_CONFIG_NAT64_BORDER_ROUTING_ENABLE 0
+#define OPENTHREAD_CONFIG_NAT64_BORDER_ROUTING_ENABLE 1
+#define OPENTHREAD_CONFIG_NAT64_TRANSLATOR_ENABLE 1
 #define OPENTHREAD_CONFIG_NET_DIAG_VENDOR_INFO_SET_API_ENABLE OPENTHREAD_FTD
 #define OPENTHREAD_CONFIG_NET_DIAG_VENDOR_MODEL "Nexus Simulation"
 #define OPENTHREAD_CONFIG_NET_DIAG_VENDOR_NAME "OpenThread by Google Nest"
@@ -116,7 +118,7 @@
 #define OPENTHREAD_CONFIG_SRP_CLIENT_ENABLE 1
 #define OPENTHREAD_CONFIG_SRP_SERVER_ADVERTISING_PROXY_ENABLE 0
 #define OPENTHREAD_CONFIG_SRP_SERVER_ENABLE 1
-#define OPENTHREAD_CONFIG_TCP_ENABLE 0
+#define OPENTHREAD_CONFIG_TCP_ENABLE 1
 #define OPENTHREAD_CONFIG_TLS_ENABLE 0
 #define OPENTHREAD_CONFIG_TMF_ADDRESS_CACHE_ENTRIES 256
 #define OPENTHREAD_CONFIG_TMF_ADDRESS_CACHE_MAX_SNOOP_ENTRIES 16