diff --git a/include/openthread/instance.h b/include/openthread/instance.h
index 0b47bbe99..9a61d372b 100644
--- a/include/openthread/instance.h
+++ b/include/openthread/instance.h
@@ -53,7 +53,7 @@ extern "C" {
  * @note This number versions both OpenThread platform and user APIs.
  *
  */
-#define OPENTHREAD_API_VERSION (246)
+#define OPENTHREAD_API_VERSION (247)
 
 /**
  * @addtogroup api-instance
diff --git a/include/openthread/nat64.h b/include/openthread/nat64.h
index 09a26b87c..73860fc8a 100644
--- a/include/openthread/nat64.h
+++ b/include/openthread/nat64.h
@@ -408,7 +408,7 @@ otError otIp4AddressFromString(const char *aString, otIp4Address *aAddress);
  * @returns  OT_ERROR_INVALID_STATE  No valid NAT64 prefix in the network data.
  *
  */
-otError otNat64SynthersizeIp6Address(otInstance *aInstance, const otIp4Address *aIp4Address, otIp6Address *aIp6Address);
+otError otNat64SynthesizeIp6Address(otInstance *aInstance, const otIp4Address *aIp4Address, otIp6Address *aIp6Address);
 
 /**
  * @}
diff --git a/src/cli/cli.cpp b/src/cli/cli.cpp
index e1f84c040..d11f728ed 100644
--- a/src/cli/cli.cpp
+++ b/src/cli/cli.cpp
@@ -472,7 +472,7 @@ otError Interpreter::ParseToIp6Address(otInstance *  aInstance,
 
         // Do not touch the error value if we failed to parse it as an IPv4 address.
         SuccessOrExit(aArg.ParseAsIp4Address(ip4Address));
-        SuccessOrExit(error = otNat64SynthersizeIp6Address(aInstance, &ip4Address, &aAddress));
+        SuccessOrExit(error = otNat64SynthesizeIp6Address(aInstance, &ip4Address, &aAddress));
         aSynthesized = true;
     }
 
diff --git a/src/cli/cli.hpp b/src/cli/cli.hpp
index afc40a85e..8c51cd0e9 100644
--- a/src/cli/cli.hpp
+++ b/src/cli/cli.hpp
@@ -238,7 +238,7 @@ public:
     /**
      * This method parses the argument as an IP address.
      *
-     * If the argument string is an IPv4 address, this method will try to synthersize an IPv6 address using preferred
+     * If the argument string is an IPv4 address, this method will try to synthesize an IPv6 address using preferred
      * NAT64 prefix in the network data.
      *
      * @param[in]  aInstance       A pointer to openthread instance.
diff --git a/src/core/api/nat64_api.cpp b/src/core/api/nat64_api.cpp
index 5e16c284d..c64e3ff35 100644
--- a/src/core/api/nat64_api.cpp
+++ b/src/core/api/nat64_api.cpp
@@ -116,7 +116,7 @@ otError otIp4AddressFromString(const char *aString, otIp4Address *aAddress)
     return AsCoreType(aAddress).FromString(aString);
 }
 
-otError otNat64SynthersizeIp6Address(otInstance *aInstance, const otIp4Address *aIp4Address, otIp6Address *aIp6Address)
+otError otNat64SynthesizeIp6Address(otInstance *aInstance, const otIp4Address *aIp4Address, otIp6Address *aIp6Address)
 {
     otError                          err = OT_ERROR_NONE;
     NetworkData::ExternalRouteConfig nat64Prefix;