diff --git a/requirements/build/tpu.txt b/requirements/build/tpu.txt
new file mode 100644
index 00000000000..cb0a541fe1d
--- /dev/null
+++ b/requirements/build/tpu.txt
@@ -0,0 +1,7 @@
+--extra-index-url https://download.pytorch.org/whl/cpu
+cmake>=3.26.1
+ninja
+setuptools>=77.0.3,<81.0.0
+setuptools-scm>=8
+torch==2.11.0+cpu
+wheel
diff --git a/tools/vllm-tpu/build.sh b/tools/vllm-tpu/build.sh
index aa46a5298bf..226439ce58f 100755
--- a/tools/vllm-tpu/build.sh
+++ b/tools/vllm-tpu/build.sh
@@ -79,12 +79,15 @@ trap cleanup EXIT HUP INT QUIT PIPE TERM # Register cleanup function to run on s
 
 echo "Updating pyproject.toml completed. Proceeding with build..."
 
+echo "Install dependencies for no-isolation build"
+pip install -r "$VLLM_DIR/requirements/build/tpu.txt"
+
 echo "Building wheel for TPU..."
 rm -rf dist/
 mkdir -p dist/
 
 # User confirmed to use 'python -m build' directly
-if ! VLLM_TARGET_DEVICE=tpu python -m build; then
+if ! VLLM_TARGET_DEVICE=tpu python -m build --no-isolation; then
     echo "Error: Python build command failed. Check if 'python -m build' works and the 'build' module is installed."
     exit 1
 fi